Chinese Journal of Magnetic Resonance ›› 2022, Vol. 39 ›› Issue (3): 316-326.doi: 10.11938/cjmr20222998

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Study on the Automatic Accumulation-thawing Device of Hyperpolarized 129Xe

Xiao-ming CHEN1,2,Xiu-chao ZHAO1,2,Xian-ping SUN1,2,Jun-shuai XIE1,2,Hai-dong LI1,2,Ye-qing HAN1,2,Xiao-ling LIU1,2,Qi CHEN1,2,Xin ZHOU1,2,*()   

  1. 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2022-04-14 Online:2022-09-05 Published:2022-05-12
  • Contact: Xin ZHOU E-mail:xinzhou@wipm.ac.cn

Abstract:

Due to the detection sensitivity provided by the high nuclear spin polarization, hyperpolarized 129Xe has been employed in animal and human magnetic resonance imaging (MRI). However, during the accumulation-thawing process of hyperpolarized 129Xe, multiple factors lead to the relaxation of spin polarization and would hinder the wider application of 129Xe. In this research, the spin relaxation mechanism of hyperpolarized 129Xe during the accumulation-thawing process is investigated by both theoretical model analysis and experimental measurements. Meanwhile, the stability of the homebuilt device for the accumulation-thawing is measured. Our results demonstrate that the thawing mode and the cold trap material significantly affect the polarization loss; the automatic device is very stable during long-term operation and shows a high degree of automation, resulting in a polarization recovery ratio of 85.6% ± 4.7%. This research greatly helps to improve the efficiency of hyperpolarized 129Xe in animal and human MRI.

Key words: magnetic resonance imaging, hyperpolarized 129Xe gas, automatic accumulation-thawing device, recovery ratios of polarization

CLC Number: