Review of a New Molecular Imaging Method——Deuterium Metabolic Spectroscopy and Imaging

doi:10.11938/cjmr20222999

Abstract

Abstract:

Commonly used molecular imaging methods include positron emission tomography (PET), hydrogen magnetic resonance spectroscopy (¹H MRS) and imaging (¹H MRSI), chemical exchange saturation transfer (CEST), and hyperpolarized ¹³C MRSI. As a cutting-edge molecular imaging method, deuterium metabolic spectroscopy (DMS) and imaging (DMI) has been recently developed and it distinguishes different tissues according to their specific glycometabolism. Compared with other molecular imaging methods, this promising technique has apparent advantages such as no radioactivity, good stability, and easy to maneuver. In this article, we review the progress of DMS/DMI and discuss its significance, future development, and potential clinical applications.

Key words: magnetic resonance, metabolic imaging, glucose, deuterium, tumor

CLC Number:

O482.53

Yi ZHANG,Fei-yang LOU,Ke FANG,Gao CHEN,Xiao-tong ZHANG. Review of a New Molecular Imaging Method——Deuterium Metabolic Spectroscopy and Imaging[J]. Chinese Journal of Magnetic Resonance, 2022, 39(3): 356-365.

Figures/Tables 3

Fig.1

Table 1

Fig.2

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文献	氘代底物	物种	场强/T	器官组织	研究内容及结论
[7]	葡萄糖	大鼠	11.7	脑、肝	可检测出脑胶质瘤中糖代谢异常（Warburg效应）；但无法区分肝脏中的糖原和葡萄糖
[7]	葡萄糖	人	4	脑、肝	可检测出脑胶质瘤中糖代谢异常（Warburg效应）；但无法区分肝脏中的糖原和葡萄糖
[10]	葡萄糖	大鼠	16.4	脑	可检测脑葡萄糖代谢速率
[13]	葡萄糖	小鼠	9.4	淋巴瘤	早期检测肿瘤组织化疗后糖代谢变化
[16]	延胡索酸	小鼠	7	乳腺癌	早期检测肿瘤组织化疗后糖代谢变化
[17]	葡萄糖	小鼠	11.7	肝	难以检测肝脏中的糖原代谢
[19]	葡萄糖	大鼠	9.4	脑	检测中风相关区域糖代谢变化
[20]	葡萄糖	大鼠	9.4	棕色脂肪	检测寒冷刺激下棕色脂肪代谢变化
[21]	乙酸盐	大鼠	16.4	心肌	不同情况下心肌细胞对能量底物的偏好
[22]	葡萄糖	大鼠	4.7	脑	氘与非超极化¹³C成像的信号强度比较
[23]	葡萄糖	小鼠	14.1	肝细胞	氘成像过程中代谢产生的重水含量变化
[24]	葡萄糖	大鼠	11.7	脑	检测氘代谢过程中因氢氘化学交换而损失的氘信号
[25]	葡萄糖	大鼠	9.4	脑	以氢氘化学交换产生的氢信号差值反映氘代谢物变化
[26]	葡萄糖	大鼠	11.7	脑	检测氘信号强度等参数随场强提高而产生的变化
[26]	葡萄糖	人	7	脑	检测氘信号强度等参数随场强提高而产生的变化
[27]	葡萄糖	人	9.4	脑	硬件提升提高氘成像的时空分辨率
[28]	葡萄糖	小鼠	9.4	黑色素瘤	氘波谱相关硬件设计
[30]	葡萄糖	小鼠	15.2	胰腺	多回波bbSP序列的信噪比高于CSI
[31]	葡萄糖	大鼠	16.4	脑	机器学习提高氘成像信噪比
[34]	葡萄糖	小鼠	14.1	脑	利用氘波谱成像检测肿瘤组织负荷及其对化疗的反应

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