Chinese Journal of Magnetic Resonance ›› 2007, Vol. 24 ›› Issue (4): 475-479.

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NGR Peptide Binding to Human Breast Cancer Cell Studied by NMR Spectroscopy

WU Chang-lin1*,YE Hai-feng2,HUANG Jing2,WU Zi-rong2   

  1. 1.Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, Department of Physics, East China Normal University; 
    2.Scholl of Life Science East China Normal University; Shanghai 200062, China
  • Received:2007-08-28 Online:2007-12-05 Published:2007-12-05
  • About author:*Corresponding author:Wu Chang-lin,Tel:021-62233281,E-mail:clwu@phy.ecnu.edu.cn.
  • Supported by:

    上海市功能磁共振成像重点实验室(华东师范大学)开放课题基金资助(FMRI061208).

Abstract:

NRG is a specific peptide with targeting binding affinity to tumor blood vessel. In this study, tumor-targeting functional peptides were constructed by connecting NGR peptide with functional peptides. To study the interaction between the constructed peptides with human breast cancer cell, binding epitope and affinity were measured with NMR spectroscopy. The spectroscopic and relaxation data showed that these peptides can bind to human breast cancer cell with high affinity.

Key words: NMR, interaction, T2 relaxation, NGR peptide

CLC Number: