NMR Spectra of Pancreatic Fluids Can Be Used to Differentiate Chronic Pancreatitis from Pancreatic Cancer

Chinese Journal of Magnetic Resonance ›› 2007, Vol. 24 ›› Issue (4): 480-486.

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NMR Spectra of Pancreatic Fluids Can Be Used to Differentiate Chronic Pancreatitis from Pancreatic Cancer

FANG Fang¹, HE Xin-hong², LU Jian-ping², CHEN Qun¹, YU Yi-hua^1*

1.Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, Department of Physics, East China Normal University, 200062 Shanghai; 
2.Department of Radiology, Changhai Hospital, The Second Military Medical University, 200433 Shanghai

Received:2007-08-28 Online:2007-12-05 Published:2007-12-05
About author:*Corresponding author:Yu Yi-hua,Tel: 021-62233281，E-mail：yhyu@phy.ecnu.edu.cn.
Supported by:
国家自然科学基金资助项目（30470514）.

Abstract

Abstract:

We applied nuclear magnetic resonance spectroscopy（NMR）to study pancreatic juice (PJ) taken from patients with chronic pancreatitis (CP) and pancreatic cancer. The aim of the study is to assign the main resonances in the ¹H NMR spectra of PJ and to discover the characteristic metabolites the changes of which can be used to differentiate CP from pancreatic cancer. 1D proton spectroscopy, 2D TOCSY and J-resolved spectra (JRES) were performed to assign the main resonances. We found a triplet at δ1.19 that only appeared in the spectra of PJ from the CP patients, but not in the spectra of PJ from the pancreatic cancer patients. The triplet was assigned to be the resonance of ethoxyl, which might be associated with the metabolism of alcohol in pancreas.

Key words: nuclear magnetic resonance spectroscopy, pancreatic juice, chronic pancreatitis, pancreatic cancer, ethoxyl

CLC Number:

R735.9

FANG Fang1, HE Xin-hong2, LU Jian-ping2, CHEN Qun1, YU Yi-hua1*. NMR Spectra of Pancreatic Fluids Can Be Used to Differentiate Chronic Pancreatitis from Pancreatic Cancer[J]. Chinese Journal of Magnetic Resonance, 2007, 24(4): 480-486.

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NMR Spectra of Pancreatic Fluids Can Be Used to Differentiate Chronic Pancreatitis from Pancreatic Cancer

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