NMR Characteristics and Conformational Analysis of (E)-3-(4-hydroxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one Derivatives

Chinese Journal of Magnetic Resonance ›› 2011, Vol. 28 ›› Issue (3): 390-398.

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NMR Characteristics and Conformational Analysis of (E)-3-(4-hydroxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one Derivatives

ZHU Chuan-Jun^1,2, ZHU Mei-Ling³, CUI Yu-Xin⁴, JIANG Biao^1*, ZHENG Jin-Hong^3*

1. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;
2. Shanghai Torch Innovation Park of Fine Chemical Industry Analysis Center, Shanghai 201512, China;
3. Medical College, Shantou University, Shantou 515031, China; 
4. State Key Laboratory of Natural and Biomimetic Drugs (Peking University), Beijing 100191, China

Received:2010-11-10 Revised:2011-03-04 Online:2011-09-05 Published:2011-09-05

Abstract

Abstract:

A new series of (E)-3-(4-hydroxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one derivatives were designed and synthesized. ¹H and ¹³C NMR spectral assignments of these compounds were presented by one- and two- dimensional NMR experiments and conformations were analyzed by ROESY, variable-temperature NMR spectroscopy and molecular modeling.

Key words: NMR, assignment, 2D NMR, (E)-3-(4-hydroxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one derivatives, conformational analysis

CLC Number:

O482.53
O641

ZHU Chuan-Jun, ZHU Mei-Ling, CUI Yu-Xin, JIANG Biao, ZHENG Jin-Hong. NMR Characteristics and Conformational Analysis of (E)-3-(4-hydroxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one Derivatives[J]. Chinese Journal of Magnetic Resonance, 2011, 28(3): 390-398.

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NMR Characteristics and Conformational Analysis of (E)-3-(4-hydroxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one Derivatives

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