NMR Characterization of a Novel Curcumol Derivative

Chinese Journal of Magnetic Resonance ›› 2011, Vol. 28 ›› Issue (3): 399-406.

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NMR Characterization of a Novel Curcumol Derivative

CAO Xue, LI Yue-Qing, LIU Ji-Hong, ZHAO Wei-Jie^*

School of Pharmaceutical Science and Technology, Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China

Received:2010-01-19 Revised:2010-03-04 Online:2011-09-05 Published:2011-09-05
Contact: ZHAO Wei-Jie E-mail:zyzhao@dlut.edu.cn
Supported by:
中央高校基本科研业务费资助项目.

Abstract

Abstract:

The structure of curcumol was modified via a two-step reaction: exocyclic double bond oxidation and oxygen bridges acylation within the seven-membered ring. The reaction product was purified by silica gel column chromatography. Compound 2 was characterized by IR, ESI-MS, ¹H NMR, ¹³C NMR and 2D NMR (i.e., gCOSY, gHSQC and gHMBC) techniques. The ¹H and ¹³C NMR signals of compound 2 were assigned. Its structure was elucidated as 8-hydroxyl -12-isopropyl-2-methyl-tricyclo[6.2.2.0^1,5] dodecane-10-oxa-6, 9-dione.

Key words: NMR, chemical shift, 2D NMR, curcumol derivatives

CLC Number:

O629.9

CAO Xue, LI Yue-Qing, LIU Ji-Hong, ZHAO Wei-Jie. NMR Characterization of a Novel Curcumol Derivative[J]. Chinese Journal of Magnetic Resonance, 2011, 28(3): 399-406.

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NMR Characterization of a Novel Curcumol Derivative

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