Abstract:

This study investigates the correlation between ¹²⁹Xe ventilation functional MRI and CT-detected pulmonary lesion types. We performed ¹²⁹Xe ventilation functional MRI and CT scans on a sample of 143 patients, subsequently analyzing the relationship between lung ventilation function at the lobe level and CT lesion types. The findings suggest that the ventilation function of the majority of lung lobes (74.6%) correlates with CT lesion types, particularly in instances of mixed diseases and emphysema, which are more prone to induce lung ventilation dysfunction Moreover, distinct ventilation patterns are observed among different lesion types. That is, the data from both ¹²⁹Xe ventilation functional MRI and CT provide complementary insights. The preliminary finding of this study offers data support for evaluating lung ventilation function and lesion diagnosis, and provide more references for imaging in diagnosis, thereby contributing to the refinement of diagnostic and therapeutic strategies for pulmonary diseases.

Key words: Hyperpolarized 129Xe MRI, pulmonary ventilation functional MRI, chest CT, lung diseases