Chinese Journal of Magnetic Resonance ›› 2024, Vol. 41 ›› Issue (4): 363-372.doi: 10.11938/cjmr20243106

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Assessment of Pulmonary Function Changes of AECOPD with Hyperpolarized 129Xe MR

LI Lianjie1,4,#, ZHENG Yu2,3,#, XIE Shuguang4,6, ZHANG Ming2, LI Hongchuang2,5, LIU Xiaoling2,5, ZHAO Xiuchao2,5, HAN Yeqing2,5, LI Haidong2,5, FAN Li4, XIAO Yi4, LIU Shiyuan4,§(), ZHOU Xin2,5,*()   

  1. 1. University of Shanghai for Science and Technology, Shanghai 200093, China
    2. State Key Laboratory of Spectroscopy and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Wuhan 430071, China
    3. Huazhong University of Science and Technology, Wuhan 430074, China
    4. Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China
    5. University of Chinese Academy of Sciences, Beijing 100049, China
    6. School of Medical Imaging, Xuzhou Medical University, Xuzhou 221000, China
  • Received:2024-03-28 Published:2024-12-05 Online:2024-04-13
  • Contact: * Tel: 027-87198631, E-mail: xinzhou@wipm.ac.cn;§ Tel: 021-81886012, E-mail: cjr.liushiuyuan@vip.163.com.

Abstract:

The acute exacerbation of chronic obstructive pulmonary disease (AECOPD) constitutes a significant adverse event in the trajectory of COPD. In this study, we utilized hyperpolarized 129Xe magnetic resonance (MR) to explore the alterations in alveolar microstructure and pulmonary gas exchange function in an AECOPD disease model. Our findings revealed that, in comparison to the emphysema group, the microstructure remained relatively unchanged in the acute exacerbation group, while gas exchange function exhibited a decrease. Notably, these observed changes correlated well with histological findings and pulmonary function assessments, indicating the feasibility and sensitivity of hyperpolarized 129Xe MR in detecting AECOPD.

Key words: hyperpolarized 129Xe MR, DWI, CSSR, COPD, emphysema, acute exacerbation

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