The Impact of K-Space Filling Strategy on Fat Artifacts in APT Imaging Based on FLASH Sequence

doi:10.11938/cjmr20243113

Abstract

Abstract:

In chemical exchange saturation transfer (CEST) imaging, the relaxation recovery of longitudinal magnetization during the signal acquisition process results in a decrease in CEST contrast. Consequently, the CEST saturation mode and the corresponding K-space filling method significantly influence both the image quality and quantitative results of CEST. In this paper, simulations and human experiments were conducted to examine the impact of various K-space filling strategies within the fast low angle shot (FLASH) sequence on the quality of brain amide proton transfer (APT) images and on the quantitative analysis of magnetization transfer ratio asymmetry (MTR_asym). The result indicates that employing segmented saturation techniques with optimized reordered center-out K-space filling technology can effectively mitigate artifacts caused by scalp fat and enhance the accuracy of MTR_asym values.

Key words: magnetic resonance imaging (MRI), chemical exchange saturation transfer (CEST), fat artifact, segmented acquisition, K-space reordering

CLC Number:

O482.53

PANG Qifan, WANG Zhichao, WU Yupeng, LI Jianqi. The Impact of K-Space Filling Strategy on Fat Artifacts in APT Imaging Based on FLASH Sequence[J]. Chinese Journal of Magnetic Resonance, 2024, 41(4): 443-453.

Figures/Tables 8

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	质子密度	T₁/ms	T₂^*/ms	饱和幅度/%
皮下脂肪（δ -3.5）	91.1%	382	68	80
大脑白质（δ 3.5）	68.6%	1087	56	10

K空间相位编码顺序	单次饱和与顺序采集	单次饱和与中心优先采集	分段饱和与顺序采集	分段饱和与中心优先采集	分段饱和与重排中心优先采集
1	1	127	#1-1	#4-31	#3-32
2	2	125	#1-2	#4-29	#1-32
:	:	:	:	:	:
16	16	97	#1-16	#4-1	#1-25
17	17	95	#1-17	#3-31	#3-24
:	:	:	:	:	:
32	32	65	#1-32	#3-1	#1-17
33	33	63	#2-1	#2-31	#3-16
:	:	:	:	:	:
48	48	33	#2-16	#2-1	#1-9
49	49	31	#2-17	#1-31	#3-8
:	:	:	:	:	:
63	63	3	#2-31	#1-3	#3-1
64	64	1	#2-32	#1-1	#1-1
65	65	2	#3-1	#1-2	#2-1
66	66	4	#3-2	#1-4	#4-1
:	:	:	:	:	:
80	80	32	#3-16	#1-32	#4-8
81	81	34	#3-17	#2-2	#2-9
:	:	:	:	:	:
96	96	64	#3-32	#2-32	#4-16
97	97	66	#4-1	#3-2	#2-17
:	:	:	:	:	:
112	112	96	#4-16	#3-32	#4-24
113	113	98	#4-17	#4-2	#2-25
:	:	:	:	:	:
127	127	126	#4-31	#4-30	#2-32
128	128	128	#4-32	#4-32	#4-32