Effects of Acute Mequindox Exposure on Urinary Metabonome in Pigs

doi:10.11938/cjmr20160305

Abstract

Abstract:

Mequindox is a member of the quinoxaline family, and widely used in Chinese veterinary industry as an antibacterial drug. Toxicity of mequindox and the underlying mechanisms have been studied previously. However, endogenous metabolic alterations in animals caused by mequindox exposure are currently unknown. This study investigated the effects of acute mequindox exposure (10 mg/kg body weight) on urinary metabonome in pigs using an NMR-based metabonomics approach. The results showed that acute mequindox exposure significantly decreased the levels of creatine, hippurate and p-cresol glucuronide in the urine of treated pigs, whereas the levels of p-cresol and benzoate increased significantly. The changes of urinary metabolic profiles were long-lasting, and did not recover at 144 h post-exposure. At the dose given, mequindox mainly caused disturbance of gut microbial ecosystem. This study provided useful information on the effects of mequindox on metabolism in pigs, and might guide the safe application of mequindox in veterinary industry.

Key words: NMR, gut microbes, urinary metabonome, mequindox

CLC Number:

O482.53

WAN Qian-fen, HE Qing-hua, WANG Yu-lan. Effects of Acute Mequindox Exposure on Urinary Metabonome in Pigs[J]. Chinese Journal of Magnetic Resonance, 2016, 33(3): 406-414.

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