Quantitative Analysis of Active Ingredients in Compound Acetylsalicylic Acid Tablets by DOSY

doi:10.11938/cjmr20160306

Abstract

Abstract:

Compound acetylsalicylic acid tablet is a clinical drug having antipyretic, analgesic and anti-inflammatory effects. The present methods to analyze the active ingredients in this drug have many disadvantages. In this study, we used polydimethylsiloxane (PDMS)-assisted diffusion ordered NMR spectroscopy (DOSY), DOSY-correlated spectroscopy (COSY), and relative quantitative ¹H NMR techniques to analyze the three main active ingredients in this drug. The content ratios among the 3 components could be obtained. It is argued that PDMS-assisted DOSY provides a convenient and efficient method for pharmaceutical quality control of compound acetylsalicylic acid tablets.

Key words: acetylsalicylic acid, pharmaceutical quality control, NMR, DOSY, polydimethylsiloxane (PDMS)

CLC Number:

O482.53

WANG Li-min, QIU Ru-chen, HUANG Shao-hua. Quantitative Analysis of Active Ingredients in Compound Acetylsalicylic Acid Tablets by DOSY[J]. Chinese Journal of Magnetic Resonance, 2016, 33(3): 415-421.

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