Stereochemical Characterization of Azabicyclo-Type Compounds by NMR Spectroscopy

Abstract

Abstract:

We present an NMR method for determining stereochemical structure of azabicyclo-type compounds, with 2-pheny-2-cycloamyl-2-hydroxyacetic-N-methly-3 azabiclo [3, 3, 1] nonane-9-carboxylate as the example. We showed that the carbon NMR spectra of azabicyclo-type compounds can be assigned effectively using the combination of multiple-frequency selective excitation double pulsed field gradient spin echo 1D NOESY and selective long-range DEPT, providing valuable information for conformation and stereo structure determination. The method presented is of significant value for studying the stereochemical characteristics and structures of azabicyclo-type compounds.

Key words: NMR, azabicyclo-type compound, 1D NOESY, selective long-range DEPT, stereochemistry

CLC Number:

O482.53

References

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