Spectroscopic Characterization of a Novel Quinoline-4-phosphoramidate Derivative

Chinese Journal of Magnetic Resonance ›› 2009, Vol. 26 ›› Issue (1): 95-102.

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Spectroscopic Characterization of a Novel Quinoline-4-phosphoramidate Derivative

YUAN Jin-wei¹；CHEN Xiao-lan^1*；QU Ling-bo^1,2；QU Zhi-bo¹； LU Jian-sha¹；ZHAO Yu-fen^1,3

(1.Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China; 2.School of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450002, China; 3.Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China)

Received:2008-10-11 Revised:2008-11-10 Online:2009-03-05 Published:2009-12-05
Contact: CHEN Xiao-lan

Abstract

Abstract: In this study, phosphoramide mustard was coupled to 2-phenyl-4-quinolone by a facile phosphorylation reaction to yield a novel quinoline-4-phosphoramidate derivative. Complete assignment of the ¹H and ¹³C NMR chemical shifts of the compound was obtained using 2D NMR techniques, including DEPT, ¹H-¹H COSY, ¹³C-¹H HSQC and ¹³C-¹H HMBC. Mass spectrum of the compound was also recorded to study its fragmentation behaviors.

Key words: NMR, chemical shift, TOF-MS, quinoline-4-phosphoramidate derivative

CLC Number:

O641

YUAN Jin-wei¹；CHEN Xiao-lan^1*；QU Ling-bo^1,2；QU Zhi-bo¹； LU Jian-sha¹；ZHAO Yu-fen^1,3
. Spectroscopic Characterization of a Novel Quinoline-4-phosphoramidate Derivative
[J]. Chinese Journal of Magnetic Resonance, 2009, 26(1): 95-102.

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Spectroscopic Characterization of a Novel Quinoline-4-phosphoramidate Derivative

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