Chinese Journal of Magnetic Resonance ›› 2008, Vol. 25 ›› Issue (2): 145-158.

• contents •     Next Articles

NMR- Approaches for Probing Fast Time Scale Dynamics of Protein Side Chains

CHENG Peng; ZHOU Zhi-ming; LI Zhao; LIU Mai-li; ZHANG Xu   

  1. State Key Laboratory of Magnetic Resonance and Molecular and Atomic Physics
    (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
  • Received:2007-05-23 Revised:2007-11-29 Online:2008-06-05 Published:2009-12-05
  • Contact: Zang Xu

Abstract:

Dynamic aspects of proteins are increasingly recognized as being important for describing their biological functions such as protein-protein and protein-drug interactions. Consequently, considerable efforts have been made to characterize protein dynamic motions. Among these methods, nuclear magnetic resonance (NMR), in particular, is capable of providing valuable information on the nature of internal motions of proteins in solution. In this review, the NMR-based approaches for studying protein side chain dynamics are reviewed, with emphasis on those methods for probing fast time scale internal motions.

Key words: NMR, protein, side chain, dynamics, relaxation