Chinese Journal of Magnetic Resonance ›› 2004, Vol. 21 ›› Issue (3): 317-321.

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AN NMR STUDY OF A NOVEL CIPROFLOXACIN DERIVATIVE: A POTENTIAL ANTIBACTERIAL AGENT

 LI Ying-Jun1*, LIU Su-Na1, JIN Kun2, PENG Qin-Ji2, SUN Shu-Qin1, XU Yong-Ting1, WANG Ying1   

  1. 1.School of Chemical Engineering, Liaoning Normal University, Dalian 116029, China; 
    2.State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China
  • Received:2004-03-01 Revised:2004-04-28 Online:2004-09-05 Published:2004-09-05

Abstract:

NMR spectroscopy was used to study a potential antibacterial agent, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-phenylacetylaminothiocarbamoyl-1-piperazinyl)-3-quinolinecarboxylic acid. The 1H and 13C NMR chemical shifts of the compound were assigned using 1]H-1H COSY, gHMBC and attached proton test (APT)  experiments.

Key words: NMR, assignment, 2D NMR, 1-cyclopropyl-6-fluoro-7-(4-phenylacetylamino-thiocarbamoyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, ciprofloxacin

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