Chinese Journal of Magnetic Resonance ›› 2021, Vol. 38 ›› Issue (3): 345-355.doi: 10.11938/cjmr20212890
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Ying-dan HU1,2,Yue CAI1,2,Xu-xia WANG1,2,Si-jie LIU1,2,Yan KANG1,2,Hao LEI1,2,Fu-chun LIN1,2,*(
)
Received:2021-02-23
Online:2021-09-05
Published:2021-03-31
Contact:
Fu-chun LIN
E-mail:fclin@wipm.ac.cn
CLC Number:
Ying-dan HU,Yue CAI,Xu-xia WANG,Si-jie LIU,Yan KANG,Hao LEI,Fu-chun LIN. Magnetic Resonance Imaging the Brain Structures Involved in Nicotine Susceptibility in Rats[J]. Chinese Journal of Magnetic Resonance, 2021, 38(3): 345-355.
Fig.1
Timeline of experimental procedures
Fig.2
The effect of nicotine administration on the dependence score of rats. (a) The effect of nicotine administration and administration time on dependence score; (b) The effect of nicotine administration on the relative dependence score. The data are presented in the form of mean±standard deviation, *p < 0.000 1
Fig.3
The PrL GM volume of rats in the Nic group is significantly correlated with DD and DR. (a) The PrL_R of rats in the Nic group; (b) PrL_R GM volume of rats in the Nic group is significantly negatively correlated with DD (r=-0.768, p=0.000 8); (c) PrL_R GM volume of rats in the Nic group is significantly positively correlated with DR (r=0.787, p=0.000 5); (d) The PrL_L of rats in the Nic group; (e) PrL_L GM volume of rats in the Nic group is significantly negatively correlated with DD (r=-0.740, p=0.001 6); (f) PrL_L GM volume of rats in the Nic group is significantly positively correlated with DR (r=0.752, p=0.001 2)
Fig.4
The GI_L GM volume of rats in the Nic group is significantly correlated with DD and DR. (a) The GI_L of rats in the Nic group; (b) GI_L GM volume of rats in the Nic group is significantly negatively correlated with DD (r=-0.683, p=0.005); (c) GI_L GM volume of rats in the Nic group is significantly positively correlated with DR (r=0.699, p=0.003 8)
Fig.5
The CA1_R GM volume of rats in the Nic group is significantly correlated with DD and DR. (a) The CA1_R of rats in the Nic group; (b) CA1_R GM volume of rats in the Nic group is significantly positively correlated with DD (r = 0.735, p = 0.001 8); (c) CA1_R GM volume of rats in the Nic group is significantly negatively correlated with DR (r = -0.743, p = 0.001 5)
Fig.6
The Thalamus_L GM volume of rats in the Nic group is significantly correlated with DD and DR. (a) The Thalamus_L of rats in the Nic group; (b). Thalamus_L GM volume of rats in the Nic group is significantly positively correlated with DD (r=0.933, p < 0.000 1); (c) Thalamus_L GM volume of rats in the Nic group is significantly negatively correlated with DR (r=-0.882, p < 0.000 1)
Fig.7
The volume of white matter (WM) in the thalamus of rats in the Nic group was significantly correlated with DD and DR. (a) The Thalamus_R of rats in the Nic group; (b) Thalamus_R WM volume of rats in the Nic group is significantly negatively correlated with DD (r = -0.738, p=0.001 7); (c) Thalamus_R WM volume of rats in the Nic group is significantly positively correlated with DR (r=0.678, p=0.005 5); (d) The Thalamus_L of rats in the Nic group; (e) Thalamus_L WM volume of rats in the Nic group is significantly negatively correlated with DD (r = -0.705, p=0.003 3); (f) Thalamus_L WM volume of rats in the Nic group is significantly positively correlated with DR (r=0.646, p=0.009 2)
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