Chiral Recognition of Ibuprofen Enatiomers by a Chiral Thiourea in the Presence of DMAP Using NMR

doi:10.11938/cjmr20140410

Abstract

Abstract:

The chiral recognition of racemic ibuprofen by thiourea was studied using ¹H NMR spectroscopy. It was found that, with the participation of DMAP, excellent
recognition of the enantiomers of ibuprofen by thiourea could be achieved, and the process was not affected by the chiral bisthiourea and DMAP. To evaluate the ability of the chiral bisthiourea/DMAP for enantiomeric determination, several ee. values of ibuprofen samples were determined by ¹H NMR, and the results coincided with the theoretical value.

Key words: NMR, DMAP, ibuprofen, chiral thiourea, enantiomeric purity

CLC Number:

O657.2

MA Min-shan，LEI Xin-xiang*. Chiral Recognition of Ibuprofen Enatiomers by a Chiral Thiourea in the Presence of DMAP Using NMR[J]. Chinese Journal of Magnetic Resonance, 2014, 31(4): 564-571.

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