In this article, we investigate the distribution of the zeros and uniqueness of differential-difference polynomials
G(z) = (fn(fm(z) − 1)∏dj=1f(z + cj )vj )(k)− α(z),
H(z) = (fn(f(z) − 1)m∏dj=1f(z + cj )vj )(k)− α(z),
where f is transcendental entire function of finite order, cj(j = 1, 2, · · · , d), n, m, d, and vj (j = 1, 2, · · · , d) are integers, and obtain some theorems, which extended and improved many previous results.