This paper is concerned with the following nonlinear fractional differential equations multi-point boundary value problem
Dα0+u(t) = f(t, u(t), Dα-10+u(t), Dα-20+u(t), Dα-30+u(t)), t ∈(0,1),
u(0) = 0, Dα-10+u(0)=∑mi=1αiDα-10+u(ξi),
Dα-20+u(1)=∑j=1nβjDα-20+u(ηj), Dα-30+u(1)-Dα-30+u(0)=Dα-20+u(1) 1/2Dα-10+u(0).
By applying Mawhin coincidence degree theory, we obtain the existence of the solutions for the problem. The results expand the previous ones in the field.