A NMR STUDY OF METOLAZONE

Abstract

Abstract:

Metolazone is a well-known quinazolinone diuretic widely used for the treatment of congestive heart failure and high blood pressure. Metolazone was first synthesized in 1967 with its first detailed pharmacological evaluation done in 1969. Previous results only reported part of its ¹H NMR data, and the detailed elucidation is yet to be performed. In this paper, using a combination of 1D and 2D NMR
techniques, the ¹H and ¹³C NMR spectra of metolazone were completely assigned and analyzed. The characteristics of its NMR data were also discussed.

Key words: NMR, metolazone, conformational isomer

CLC Number:

O641

DONG Jian-Jun, WU Ming-Jian, ZHANG Hai-Yan, FU Jing-Guo, CHEN Tao, ZHAO Tian-Zeng. A NMR STUDY OF METOLAZONE[J]. Chinese Journal of Magnetic Resonance, 2004, 21(1): 93-97.

References

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