SYNTHESIS OF PHOSPHORYLATED AMINOPHENOLS AND DIHYDROXYBENZENES BY THE ATHERON-TODD REACTION AND THEIR NMR CHARACTERIZATION

Chinese Journal of Magnetic Resonance ›› 2004, Vol. 21 ›› Issue (1): 87-91.

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SYNTHESIS OF PHOSPHORYLATED AMINOPHENOLS AND DIHYDROXYBENZENES BY THE ATHERON-TODD REACTION AND THEIR NMR CHARACTERIZATION

CHEN Xiao-Lan^1*, YU You-Zhu¹, LU Jian-Sha¹, CHEN-Li¹, QU Ling-Bo¹, LIAO Xin-Cheng¹, ZhAO Yu-Fen^1,2

1.Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China; 
2.The Key Laboratory for Bioorganic Phosphorus Chemistry, the Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

Received:2003-06-10 Revised:2003-07-21 Online:2004-03-05 Published:2004-03-05
Supported by:
国家自然科学基金资助项目(39870415)和2001河南省省拨院士基金资助项目.

Abstract

Abstract:

The Atheron-Todd reaction has been applied extensively to the synthesis of phosphates and phosphoroamidates. In this study, aminophenols and dihydroxybenzenes were phosphoylated by a modified Atheron-Todd procedure, in which DEPH and etrachloromethane were added to the mixed solution of phenol, triethylamine and dioxane and the mixed solution of phenols, triethylamine and dioxane, respectively. The target phosphates were obtained with good yields. Their structures were elucidated by NMR and ESI-MS.

Key words: NMR, ESI-MS, phosphorylation, aminophenols, dihydroxybenzenes, diethyl phophite (DEPH)

CLC Number:

O627. 51

CHEN Xiao-Lan, YU You-Zhu, LU Jian-Sha, CHEN-Li, QU Ling-Bo, LIAO Xin-Cheng, ZhAO Yu-Fen. SYNTHESIS OF PHOSPHORYLATED AMINOPHENOLS AND DIHYDROXYBENZENES BY THE ATHERON-TODD REACTION AND THEIR NMR CHARACTERIZATION[J]. Chinese Journal of Magnetic Resonance, 2004, 21(1): 87-91.

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SYNTHESIS OF PHOSPHORYLATED AMINOPHENOLS AND DIHYDROXYBENZENES BY THE ATHERON-TODD REACTION AND THEIR NMR CHARACTERIZATION

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