NMR method for Determining Energy Metabolism and Neurotransmission Kinetics in Brain

Abstract

Abstract:

Energy metabolism and neurotransmission are fundamental to all brain functions and their abnormalities are invariably the causes of various neurogenic or psychotic diseases. Therefore, understanding energy metabolism and neurotransmission has long been one of the major topics in the brain research, particularly essential for revealing the mechanism of brain functions. While it is well-known that glucose is the main energy source of the brain, it has been difficult to quantitatively measure the metabolic kinetics and the neurotransmission in vivo. Owing to their unique advantages, nuclear magnetic resonance (NMR) method has quickly emerged as one type of the most important tool in the field. In this paper, the principle and techniques of the relevant NMR methods as well as their applications in the studies of metabolic kinetics and neurotransmission are comprehensively reviewed.

Key words: NMR, energy metabolism, ¹H-[¹³C]-NMR, , neurotransmission kinetics, , tricarboxylic acid cycle

CLC Number:

O482.53

WANG Jie, LIU Qing, JIANG Li-Hong, XU Fu-Qiang. NMR method for Determining Energy Metabolism and Neurotransmission Kinetics in Brain[J]. Chinese Journal of Magnetic Resonance, 2010, 27(3): 341-354.

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