Recent Progress in Development of Bio-Active MRI Contrast Agents

Abstract

Abstract:

Bio-activated MRI contrast agents are often called “enzyme activated”, “bio-responsive” or “smart” contrast agents because they respond, specifically, to enzymatic activity, metal ion concentration, pH et al factors, respectively. Recent progress in the development of bioactivated MRI contrast agents is reviewed with the emphasis on the design principle of contrast generation based on the analysis of the structure, properties and functions of these compounds.

Key words: magnetic resonance imaging (MRI), contrast agents, bio-responsive

CLC Number:

O657.2

YU Kai-Chao, LV Zhi-Yong, YAO Yao, FU Shi-Tao, DING Shang-Wu, ZHOU Jin-Lan. Recent Progress in Development of Bio-Active MRI Contrast Agents[J]. Chinese Journal of Magnetic Resonance, 2010, 27(3): 355-368.

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