Research Progresses in Development of Thermo-Sensitive MRI Contrast Agent

doi:10.11938/cjmr20172568

Abstract

Abstract: Magnetic resonance imaging (MRI) is a practical technique for non-invasive temperature measurement. Thermo-sensitive MRI contrast agents, which cause temperature-dependent changes in magnetic resonance parameters of water molecules (i.e., relaxation, signal intensity and chemical shift) have been widely applied to MRI thermometry. This paper gives an overview of the types, principle, research status and application prospects of thermo-sensitive MRI contrast agent.

Key words: magnetic resonance imaging (MRI), contrast agent, thermo-sensitive, non-invasive

CLC Number:

O482.53

LU Yao, ZHENG Xin-wei, ZHONG Kai. Research Progresses in Development of Thermo-Sensitive MRI Contrast Agent[J]. Chinese Journal of Magnetic Resonance, 2017, 34(4): 528-536.

References

[1] YANG B L. Future of ultra high field MRI in basic research and clinical applications[J]. Chinese J Magn Reson, 2015, 32(4):707-714. 杨保联. 超高场磁共振人体成像应用研究和医学前景[J]. 波谱学杂志, 2015, 32(4):707-714.[2] ZHANG H Y, LI C L, YING X F, et al. A Gadolinium based T1 MRI probe for detection of lung cancer stem cells[J]. Chinese J Magn Reson, 2016, 33(4):623-674. 张宏岩, 李春林, 英晓芳, 等. 靶向肺癌干细胞的多肽Gd基T1型MRI探针的研究[J]. 波谱学杂志, 2016, 33(4):623-674.[3] THORARINSDOTTIR A E, GAUDETTE A I, HARRIS T D. Spin-crossover and high-spin iron(Ⅱ) complexes as chemical shift 19F magnetic resonance thermometers[J]. Chem Sci, 2017, 8(3):2448-2456.[4] FERNANDO W S, MARTINS A F, ZHAO P, et al. Breaking the barrier to slow water exchange rates for optimal magnetic resonance detection of paraCEST agents[J]. Inorg Chem, 2016, 55(6):3007-3014.[5] DECKERS R, SPRINKHUIZEN S M, CRIELAARD B J, et al. Absolute MR thermometry using nanocarriers[J]. Contrast Media Mol, 2014, 9(4):283-290.[6] QUESSON B, LAURENT C, MACLAIR G, et al. Real-time volumetric MRI thermometry of focused ultrasound ablation in vivo:A feasibility study in pig liver and kidney[J]. NMR Biomed, 2011, 24(2):145-153.[7] YU K C, LV Z Y, YAO Y, et al. Recent progress in development of bio-active MRI contrast agents[J]. Chinese J Magn Reson, 2010, 27(3):355-368. 俞开潮, 吕志勇, 姚遥, 等. 生物激活磁共振成像造影剂的研究进展[J]. 波谱学杂志, 2010, 27(3):355-368.[8] YU K C, WANG G P, DING S W, et al. Recent Progeresses in the development of contrate agents used in megnetic resonance imaging[J]. Chinese J Magn Reson, 2004, 21(4):506-525. 俞开潮, 王国平, 丁尚武, 等. 用于磁共振成像对比增强的造影剂研发进展[J]. 波谱学杂志, 2004, 21(4):506-525.[9] GAO T X, LV Z, DING H Y, et al. Research progress of magnetic resonance imaging thermometry[J]. Chinese Journal of Medical Imaging, 2008, 7:547-553. 高天新, 吕宙, 丁海艳, 等. 磁共振温度成像技术研究进展[J]. 中国医学影像学杂志, 2014, 7:547-533.[10] RIEKE V, PAULY K B. MR thermometry[J]. J Magn Reson Imaging, 2008, 27(2):376-390.[11] SETTECASE F, SUSSMAN M S, ROBERTS T P L. A new temperature-sensitive contrast mechanism for MRI:Curie temperature transition-based imaging[J]. Contrast Media Mol, 2007, 2(1):50-54.[12] QUESSON B, DE ZWART J A, MOONEN C T W. Magnetic resonance temperature imaging for guidance of thermotherapy[J]. J Magn Reson Imaging, 2000, 12(4):525-533.[13] BORMAN P T S, BOS C, DE BOORDER T, et al. Towards real-time thermometry using simultaneous multislice MRI[J]. Phys Med Biol, 2016, 61(17):461-477.[14] HANKIEWICZ J H, CELINSKI Z, STUPIC K F, et al. Ferromagnetic particles as magnetic resonance imaging temperature sensors[J]. Nat Commun, 2016, 7:1-8.[15] HANNECART A, STANICKI D, VANDER ELST L, et al. Nano-thermometers with thermo-sensitive polymer grafted USPIOs behaving as positive contrast agents in low-field MRI[J]. Nanoscale, 2015, 7(8):3754-3767.[16] KIM H R, YOU D G, PARK S J, et al. MRI monitoring of tumor-selective anticancer drug delivery with stable thermosensitive liposomes triggered by high-intensity focused ultrasound[J]. Mol Pharm, 2016, 13(5):1528-1539.[17] DICHEVA B M, KONING G A. Targeted thermosensitive liposomes:an attractive novel approach for increased drug delivery to solid tumors[J]. Expert Opin Drug Del, 2014, 11(1):83-100.[18] HOSSANN M, WANG T, SYUNYAEVA Z, et al. Non-ionic Gd-based MRI contrast agents are optimal for encapsulation into phosphatidyldiglycerol-based thermosensitive liposomes[J]. J Control Release, 2013, 166(1):22-29.[19] TASHJIAN J A, DEWHIRST M W, NEEDHAM D, et al. Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques[C]//Symposium of the European-Society-for-Hyperthermic-Oncology, Prague, CZECH REPUBLIC. European Soc Hypertherm Oncol, 2008, 24(1):79-90.[20] FOSSHEIM S L, IL'YASOV K A, HENNIG J, et al. Thermosensitive paramagnetic liposomes for temperature control during MR imaging-guided hyperthermia:In vitro feasibility studies[J]. Acad Radiol, 2000, 7(12):1107-1115.[21] FOSSHEIM S L, FAHLVIK A K, KLAVENESS J, et al. Paramagnetic liposomes as MRI contrast agents:Influence of liposomal physicochemical properties on the in vitro relaxivity[J]. Magn Reson Imaging, 1999, 17(1):83-89.[22] DAVIES G L, KRAMBERGER I, DAVIS J J. Environmentally responsive MRI contrast agents[J]. Chem Commun, 2013, 49(84):9704-9721.[23] TAGAMI T, FOLTZ W D, ERNSTING M J, et al. MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome[J]. Biomaterials, 2011, 32(27):6570-6578.[24] DE SMET M, HEIJMAN E, LANGEREIS S, et al. Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes:An in vivo proof-of-concept study[J]. J Control Release, 2011, 150(1):102-110.[25] LINDNER L H, REINL H M, SCHLEMMER M, et al. Paramagnetic thermosensitive liposomes for MR-thermometry[J]. Int J Hyperthermia, 2005, 21(6):575-588.[26] HEFFERN M C, MATOSZIUK L M, MEADE T J. Lanthanide probes for bioresponsive imaging[J]. Chem Rev, 2014, 114(8):4496-4539.[27] HINGORANI D V, BERNSTEIN A S, PAGEL M D. A review of responsive MRI contrast agents:2005-2014[J]. Contrast Media Mol, 2015, 10(4):245-265.[28] ZHANG S R, MALLOY C R, SHERRY A D. MRI thermometry based on PARACEST agents[J]. J Am Chem Soc, 2005, 127(50):17572-17573.[29] LI A X, WOJCIECHOWSKI F, SUCHY M, et al. A sensitive PARACEST contrast agent for temperature MRI:Eu3+-DOTAM-Glycine (Gly)-Phenylalanine (Phe)[J]. Magn Reson Med, 2008, 59(2):374-381.[30] MCVICAR N, LI A X, SUCHY M, et al. Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent[J]. Magn Reson Med, 2013, 70(4):1016-1025.[31] MULLER R N, VANDER ELST L, LAURENT S. Spin transition molecular materials:Intelligent contrast agents for magnetic resonance imaging[J]. J Am Chem Soc, 2003, 125(27):8405-8407.[32] SIGOLAEVA L V, GLADYR S Y, GELISSEN A P H, et al. Dual-stimuli-sensitive microgels as a tool for stimulated spongelike adsorption of biomaterials for biosensor applications[J]. Biomacromolecules, 2014, 15(10):3735-3745.[33] SHIRAKURA T, KELSON T J, RAY A, et al. Hydrogel nanoparticles with thermally controlled drug release[J]. ACS Macro Lett, 2014, 3(7):602-606.[34] LI P H, XU R Z, WANG W H, et al. Thermosensitive poly(N-isopropylacrylamide-co-glycidyl methacrylate) microgels for controlled drug release[J]. Colloid Surfaces B, 2013, 101:251-255.[35] LYON L A, MENG Z, SINGH N, et al. Thermoresponsive microgel-based materials[J]. Chem Soc Rev, 2009, 38(4):865-874.[36] ZHENG X W, QIAN J C, TANG F, et al. Microgel-based thermosensitive MRI contrast agent[J]. ACS Macro Lett, 2015, 4(4):431-435.[37] BALASUBRAMANIAM S, POTHAYEE N, LIN Y, et al. Poly(N-isopropylacrylamide)-coated superparamagnetic iron oxide nanoparticles:relaxometric and fluorescence behavior correlate to temperature-dependent aggregation[J]. Chem Mater, 2011, 23(14):3348-3356.[38] SHUHENDLER A J, STARUCH R, OAKDEN W, et al. Thermally-triggered "off-on-off" response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry[J]. J Control Release, 2012, 157(3):478-484.[39] JEON I R, PARK J G, HANEY C R, et al. Spin crossover iron(Ⅱ) complexes as PARACEST MRI thermometers[J]. Chem Sci, 2014, 5(6):2461-2465.[40] ZHU X L, CHEN S Z, LUO Q, et al. Body temperature sensitive micelles for MRI enhancement[J]. Chem Commun, 2015, 51(44):9085-9088.