Comparisons of Different CEST Quantification Metrics Applied in Acute Parkinson's Disease Mouse Model

doi:10.11938/cjmr20182692

Abstract

Abstract: Non-invasive and quantifiable diagnosis of Parkinson's disease (PD) is an ongoing challenge for researchers. In this study, we compared two different chemical exchange saturation transfer (CEST) imaging quantification metrics in substantia nigra (SN), cortex and hippocampus of acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice at three different time points including before MPTP administration, and the 3^rd and 10^th day after MPTP administration. Area of amine (Area_amine), magnetization transfer ratio yielding R_ex (MTR_rex) and apparent exchange-dependent relaxation (AREX) in SN derived from 5-pool Lorentzian fitting and inverse Z-spectrum analysis showed a statistically significant decrease after successful modeling, while there were no significant alterations in T₁, T₂, and magnetization transfer ratio based on asymmetry analysis (MTR_asym). The results suggested that the former quantification is superior to that based on Z-spectrum asymmetry in vivo due to the exclusion of direct saturation (DS) and magnetic transfer (MT) effects and may reflect the destroying SN of PD.

Key words: magnetic resonance imaging (MRI), chemical exchange saturation transfer (CEST), Lorentzian fitting, inverse Zspectrum analysis, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

CLC Number:

O482.53

WEI Guo-jing, YI Pei-wei, TAO Quan, FENG Yan-qiu. Comparisons of Different CEST Quantification Metrics Applied in Acute Parkinson's Disease Mouse Model[J]. Chinese Journal of Magnetic Resonance, 2019, 36(2): 195-207.

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