Accelerating T1ρ Dispersion Imaging with Multiple Relaxation Signal Compensation

doi:10.11938/cjmr20222976

Abstract

Abstract:

Magnetic resonance imaging (MRI) can quantify characteristic values of tissues, serving as an important tool for scientific and clinical research. Magnetic resonance T_1ρ relaxation time reflects the low-frequency motional processes between water and macromolecules. At high fields of 3 T and above, T_1ρ is greatly affected by the chemical exchange between water and exchangeable protons, and T_1ρ dispersion measured with varying spin-lock fields can be utilized to analyze and quantify the proton exchange process. However, it is time-consuming to obtain T_1ρ-weighted images with different spin-lock fields, which limits its application. To solve this problem, a fast T_1ρ dispersion imaging method based on multiple relaxation signal compensation strategy is proposed in this work, which compensates the T_1ρ-weighted images at different locking frequencies to the same signal strength level, and combines the low-rank plus sparse model in the reconstruction. Experimental results show that the proposed method achieves good reconstruction results even when the acceleration factor is up to 7.

Key words: magnetic resonance quantitative imaging, T_1ρ dispersion, signal compensation, low-rank plus sparse

CLC Number:

O482.53

Yuan-yuan LIU, Yu-xin YANG, Qing-yong ZHU, Zhuo-xu CUI, Jing CHENG, Cong-cong LIU, Dong LIANG, Yan-jie ZHU. Accelerating T_1ρ Dispersion Imaging with Multiple Relaxation Signal Compensation[J]. Chinese Journal of Magnetic Resonance, 2022, 39(3): 243-257.

Figures/Tables 10

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		R=4	R=5	R=6	R=7
nRMSE	L+S	0.0538±0.0144	0.0675±0.0187	0.0835±0.0234	0.1010±0.0232
	BCS	0.0439±0.0180	0.0466±0.0117	0.0562±0.0161	0.0630±0.0166
	T_1ρ-DISC	0.0349±0.0115	0.0383±0.0147	0.0439±0.0169	0.0483±0.0187

PSNR	L+S	17.1353±0.2069	17.0752±0.2686	16.7938±0.3227	16.5361±0.3010
	BCS	17.3670±0.2014	17.4463±0.2431	17.4215±0.2504	17.3205±0.2271
	T_1ρ-DISC	17.5279±0.1981	17.6060±0.2079	17.5362±0.2544	17.4039±0.2585

SSIM	L+S	0.6785±0.0193	0.6408±0.0229	0.6033±0.0261	0.5757±0.0217
	BCS	0.6800±0.0529	0.6727±0.0184	0.6481±0.0219	0.6360±0.0210
	T_1ρ-DISC	0.7148±0.0179	0.7035±0.0223	0.6916±0.0255	0.6853±0.0268

	T_1ρ-DISC	L+S	BCS
R=4	115 min	2 min	932 min
R=5	117 min	3 min	1112 min
R=6	112 min	3 min	898 min
R=7	114 min	3 min	802 min

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