Application of Solid-State NMR to Bone and Bone Biomaterials

doi:10.11938/cjmr20170114

Abstract

Abstract: Bone, as a structural organization and an important hematopoietic organ of the human body, plays critical biological roles in protecting human organs, storing calcium and phosphorus, participating in metabolism regulation and providing attachment sites for muscles. Understanding the microstructure of bone is important for intervention and treatment of bone diseases. However, experimental characterizations of the bone has been hindered by the morphological diversity of the bone, coexistence of organic and inorganic components, and sensitivity of bone samples to physical and chemical treatment. Compared with other techniques, solid-state nuclear magnetic resonance (NMR) can study the bone in-situ without any chemical pretreatment, thus avoiding changing bone structure. In addition, most of the chemical elements in the bone are magnetic resonance detectable, such as ¹H, ¹³C, ³¹P, ¹⁹F, ⁴³Ca, ²⁹Si, ²⁵Mg and ⁸⁷Sr. Therefore, high resolution solid-state NMR technique provides a powerful tool for structural studies of the bone and bone biomaterials. In this paper, we reviewed the recent progresses in the application of solid-state NMR to bone and bone biomaterials studies.

Key words: bioglass, biomineralization, hydroxyapatite, solid-state NMR, bone

CLC Number:

O482.53

LI Dong-bei, XU Shuai, YU Zhi-wu. Application of Solid-State NMR to Bone and Bone Biomaterials[J]. Chinese Journal of Magnetic Resonance, 2017, 34(1): 115-129.

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