Heterogeneous Structure and Miscibility of Phenylboronic Acid-Rich Chitosan Nanoparticles as Revealed by Advanced Solid-State NMR

doi:10.11938/cjmr20150217

Abstract

Abstract:

By using advanced solid-state NMR techniques, the heterogeneous structure and inter-polymer miscibility of chitosan-poly (N-3-acrylamidophenyl-boronic acid) nanoparticles (CS-PAPBA NPs) were investigated. The ¹³C CPMAS experiments indicate the conformational change of chitosan when incorporated with phenyl boronic acid. Two-dimensional (2D) ¹³C-¹H HETCOR experiments further demonstrate that a portion of chitosan is closely bound with
PAPBA in the interphase by means of boronic coordination interaction. 2D ¹H-¹H spin-exchange with spin-diffusion experiments demonstrate that the interfacial mixing of chitosan and PAPBA, and micro-phase separation is of the order of 15–20 nanometers.

Key words: solid-state NMR, heterogeneous structure, miscibility, nanoparticles, chitosan

CLC Number:

O482.53

WANG Fen-fen1，CHEN Tie-hong1，SUN Ping-chuan1,2,3*. Heterogeneous Structure and Miscibility of Phenylboronic Acid-Rich Chitosan Nanoparticles as Revealed by Advanced Solid-State NMR[J]. Chinese Journal of Magnetic Resonance, 2015, 32(2): 354-362.

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