Measuring Bone Mineral Density with NMR

doi:10.11938/cjmr20160312

Abstract

Abstract:

Bone mineral density (BMD) measured by dual energy X-ray absorptiometry is often used as an index for diagnosis of osteoporosis. However, ionization radiation is present in X-ray BMD measurement, and the result can be inaccurate in some caese. In this work, we constructed an NMR equipment that used a Q-switch to achieve echo time as low as 80 ms, and thus have the potential to be used for BMD measurement. In the T₂ relaxation time spectra of bone measured by this equipment, the peak area at 300~500 ms was found to change linearly with the BMD measured by X-ray absorptiometry. Based on this observation, we put forward a method to measure in vitro BMD with NMR T₂ relaxation time spectra. This kind of method has advantages such as high measuring speed, no ionization radiation, and high cross-period comparability.

Key words: NMR, T₂ relaxation time spectrum, dual energy X-ray absorptiometry, ultra-short echo time, bone mineral density

CLC Number:

LI Cheng-wei, FAN Dong-wei, JIANG Jia-qi, DU Guo-hong, WANG Wei-min. Measuring Bone Mineral Density with NMR[J]. Chinese Journal of Magnetic Resonance, 2016, 33(3): 468-478.

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