Chinese Journal of Magnetic Resonance ›› 2017, Vol. 34 ›› Issue (1): 115-129.doi: 10.11938/cjmr20170114

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Application of Solid-State NMR to Bone and Bone Biomaterials

LI Dong-bei, XU Shuai, YU Zhi-wu   

  1. High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, China
  • Received:2016-02-02 Revised:2017-01-05 Online:2017-03-05 Published:2017-03-05

Abstract: Bone, as a structural organization and an important hematopoietic organ of the human body, plays critical biological roles in protecting human organs, storing calcium and phosphorus, participating in metabolism regulation and providing attachment sites for muscles. Understanding the microstructure of bone is important for intervention and treatment of bone diseases. However, experimental characterizations of the bone has been hindered by the morphological diversity of the bone, coexistence of organic and inorganic components, and sensitivity of bone samples to physical and chemical treatment. Compared with other techniques, solid-state nuclear magnetic resonance (NMR) can study the bone in-situ without any chemical pretreatment, thus avoiding changing bone structure. In addition, most of the chemical elements in the bone are magnetic resonance detectable, such as 1H, 13C, 31P, 19F, 43Ca, 29Si, 25Mg and 87Sr. Therefore, high resolution solid-state NMR technique provides a powerful tool for structural studies of the bone and bone biomaterials. In this paper, we reviewed the recent progresses in the application of solid-state NMR to bone and bone biomaterials studies.

Key words: bioglass, biomineralization, hydroxyapatite, solid-state NMR, bone

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