Chinese Journal of Magnetic Resonance

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NMR Signal Assignment and Solvent Effects of N-substituted Indoles

YANG Er-bing, MA Li-bo, WANG Jin-hui, YE Yong*   

  1. Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular engineering, Zhengzhou University, Zhengzhou 450052, China
  • Received:2012-06-18 Revised:2012-10-20 Online:2013-06-05 Published:2013-06-05
  • About author:*Corresponding author:Ye Yong,Tel: 0371-67767051,E-mail: yeyong@zzu.edu.cn.
  • Supported by:

    国家自然科学基金资助项目(20972143).

Abstract:

1H and 13C NMR signals of N-substituted indole derivatives were assigned using 1D and 2D NMR techniques. The effects of C-N bond rotation barrier on the 1H and 13C NMR signals in compound m was studied using variable-temperature NMR. Rotation rate and free energy were calculated under coalesce temperature. The rotation barrier dependence on the solvent effects of m was also studied. It was found that the rotation barrier about C-N in m was higher in polar solvent.

Key words: NMR, assignment, conformation, variable-temperature NMR, N-substituted indole derivatives

CLC Number: