Chinese Journal of Magnetic Resonance

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An NMR Study on 1,2-Substituted Ethylene Derivatives

JIANG Dan*,  MIAO Zhen-chun   

  1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2012-05-21 Revised:2012-07-15 Online:2013-03-05 Published:2013-03-05
  • Contact: Jiang Dan,Tel: 13671259606,E-mail:jiangdan@263.net.cn. E-mail:jiangdan@263.net.cn
  • About author:Jiang Dan,Tel: 13671259606,E-mail:jiangdan@263.net.cn.

Abstract:

The chemical structures of 1,2-substituted ethylene derivatives were studied by NMR spectroscopy. Multiple-frequency selective excitation double pulsed field gradient spin echo 1D NOESY technique was found to be effective for structural elucidation of  1,2-substituted ethylene derivatives. High-quality NOE spectra were obtained, with elimination of selective population transfer (SPT). The usefulness of 1D NOE in the structural elucidation of  1,2-substituted ethylene derivatives was demonstrated using acetic acid 4-(2-cyclohexylcarbamoyl-2-phenyl-vinyl)-2-methoxy-phenyl ester as the example.

Key words: NMR, 1,2-substituted ethylene derivatives, 1D NOE, stereochemistry

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