Interaction between Cucurbit[n]uril (n=7, 8) and Fasudil Hydrochloride Studied by NMR Spectroscopy

Abstract

Abstract:

The host-guest chemistry of systems containing fasudil hydrochloride (FSDE) and cucurbit[n]uril (CB[n], n=7, 8) was investigated by NMR, ESI-MS, UV-Vis and IR spectroscopy. The experiment results indicated that the guest fasudil hydrochloride and CB[n] (n=7, 8) host could form a stable 1∶1 (molar ratio) inclusion complex, in which the positions of CB[7] and CB[8] were different because of the sizes of their cavities. The inclusion constant of fasudil hydrochloride with CB\[7\] and CB[8] was 2 524 L/mol and 1 216 L/mol, respectively. The binding constant was in the range of 200 L/mol~10 000 L/mol, indicating that CB[7] and CB[8] could be used as possible slow-released agents.

Key words: cucurbit[n]uril, fasudil hydrochloride, inclusion complex, NMR

CLC Number:

O482.53

CHEN Xiu-Li, ZHU Wei-Guo, JIANG Song, YANG Chun-Xue, ZU Da-Feng. Interaction between Cucurbit[n]uril (n=7, 8) and Fasudil Hydrochloride Studied by NMR Spectroscopy[J]. Chinese Journal of Magnetic Resonance, 2012, 29(4): 554-563.

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