Pure and Mixed Enantiomer of Moxifloxacin Hydrochloride Studied by NMR Spectroscopy

Abstract

Abstract:

The structures of pure and mixed enantiomer of moxifloxacin hydrochloride were elucidated by NMR. The chemical shift of the spectral peaks were assigned using ¹H and ¹³C NMR, COSY, HSQC, HMBC and 2D NOESY techniques, as well as ¹⁹F-¹³C coupled splitting. It was found that ¹⁹F-¹³C coupling exists not only in the sixmembered ring, but also in the fivemembered heterocyclic ring, and that ⁴J_FCin the five-membered heterocyclic ring is larger than ³J_FC and ⁴J_FC in the sixmembered ring. The spectral characteristics of the pure and mixed enantiomer of moxifloxacin hydrochloride were summarized. A method was proposed to differentiate the pure and mixed enantiomer of moxifloxacin hydrochloride.

Key words: NMR, moxifloxacin hydrochloride, enantiomer, identification method

CLC Number:

O482.53

YANG Qiu-Qing, LIU Bo-Qian, HAN Kang. Pure and Mixed Enantiomer of Moxifloxacin Hydrochloride Studied by NMR Spectroscopy[J]. Chinese Journal of Magnetic Resonance, 2012, 29(1): 119-127.

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Pure and Mixed Enantiomer of Moxifloxacin Hydrochloride Studied by NMR Spectroscopy

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