Chinese Journal of Magnetic Resonance ›› 2011, Vol. 28 ›› Issue (3): 413-418.

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NMR Analysis of Targeted Drug Gefitinib

 CHEN Mu-Zi1*, WANG Lu1, ZHANG Hai-Lu2, LI Wan-Fei2, DING Yuan-Chen1   

  1. 1. Analysis and Testing Center, Suzhou University, Suzhou 215123, China;
     2. Suzhou Institute of NanoTech and NanoBionics, Chinese Academy of Sciences, Suzhou 215123, China
  • Received:2010-12-20 Revised:2011-02-21 Online:2011-09-05 Published:2011-09-05

Abstract:

The 13C  and 1H NMR chemical shifts of gefitinib were assigned using 1D and 2D NMR techniques, including 1H-1H COSY, gHMQC and gHMBC. The effects of 19F substitution on 1H and 13C NMR spectra of the compound were investigated.

Key words: NMR, assignment, 2D NMR, gefitinib

CLC Number: