Progress in NMRBased Studies on the Structure and Function of A3G

Abstract

Abstract:

The human A3G (apolipoprotein B messenger-RNA editing enzyme, catalytic polypeptide-like 3G) protein belongs to a family of polynucleotide cytidine deaminases, which is a human intrinsic immune protein with anti-viral activity. During the process of HIV virions replication, A3G is effectively incorporated into budding HIV-1 virions, catalyze C→U conversions, and then block viral replication, resulting in viral infectivity. In recent years, much attention has been paid on the structure and the process of deamination of A3G by NMR or X-ray, and significant research progress has been made, which might provide new ideal for further research. In this paper, we summarized these works in order to provide new reference for the prevention and treatment of AID’s and hepatitis B virus and the relative new drug design.

Key words: A3G, HIV, NMR, X-ray diffraction

CLC Number:

O482.53
Q71

DAI Yuan-Yuan, LA Wen-Xian, CHANG Cheng. Progress in NMRBased Studies on the Structure and Function of A3G[J]. Chinese Journal of Magnetic Resonance, 2011, 28(2): 290-298.

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