NMR and Stereochemistry Studies of Fexofenadine Hydrochloride

Chinese Journal of Magnetic Resonance ›› 2011, Vol. 28 ›› Issue (2): 265-271.

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NMR and Stereochemistry Studies of Fexofenadine Hydrochloride

ZHAO Yu-Mei*, TANG Li-Ge, MIAO Zhen-Chun, LIU Li-Jun

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850

Received:2010-07-13 Revised:2010-08-16 Online:2011-06-05 Published:2011-06-05

Abstract

Abstract:

Fexofenzdine hydrochloride is a second generation antihistamine drug. The complete and unequivocal assignments of the ¹H and ¹³C NMR signals of the compound are not available so far. In this paper, we assigned all protons and carbons in the compound with 1D ROESY and 1D TOCSY experiments in combination with 2D NMR techniques. The configuration of the compound was also determined.

Key words: NMR, assignment, fexofenadine, 2D NMR, 1D ROESY, 1D TOCSY, stereochemistry

CLC Number:

O482.53

ZHAO Yu-Mei, TANG Li-Ge, MIAO Zhen-Chun, LIU Li-Jun. NMR and Stereochemistry Studies of Fexofenadine Hydrochloride[J]. Chinese Journal of Magnetic Resonance, 2011, 28(2): 265-271.

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NMR and Stereochemistry Studies of Fexofenadine Hydrochloride

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