Chinese Journal of Magnetic Resonance ›› 2009, Vol. 26 ›› Issue (4): 492-496.

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NMR Study of Aβ(12-28) Peptide from Alzheimer’s Disease

  

  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • Received:2009-06-01 Revised:2009-07-17 Online:2009-12-05 Published:2009-12-05

Abstract:

Oligomerization of Aβ peptides and fibril formation play critical roles in the pathology of Alzheimer’s disease (AD). Aβ(1-42) is the most toxic species of the  Aβ peptides. Disruption of Aβ aggregation is a promising approach in developing therapeutics for AD. In our previous studies, some compounds were found to be able to bind to Aβ(12-28). In this work, two-dimensional NMR methods were used to assign the 1H and 15N chemical shifts of Aβ(12-28) peptide. The results should provide a basis for the interaction study of Aβ(12-28) peptide with small molecule inhibitors.

Key words: NMR, signal assignment, 2D NMR, (12-28) peptide

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