1H and 13C NMR Chemical Shift Assignment for Tenatoprazole

Chinese Journal of Magnetic Resonance ›› 2009, Vol. 26 ›› Issue (3): 393-399.

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¹H and ¹³C NMR Chemical Shift Assignment for Tenatoprazole

LIN Zhen-guang; LIN Ji-mao; HU Zhan-kun; CAO Zhen-yan

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China

Received:2009-01-06 Revised:2009-02-18 Online:2009-09-05 Published:2010-01-04
Contact: LIN Ji-mao

Abstract

Abstract: Tenatoprazole is a novel proton pump inhibitor currently undergoing phase III clinical trail. In this study, the ¹H and ¹³C chemical shifts of this compound were assigned using 2D NMR techniques, including DEPT, HMQC, HMBC, COSY, NOESY and TOCSY. The asymmetric structure of the compound was elucidated by NOESY. All quaternary carbons of the compound were also assigned by HMBC.

Key words: NMR, chemical shift, 2D NMR, tenatoprazole, pyridine

CLC Number:

O482.53

LIN Zhen-guang; LIN Ji-mao; HU Zhan-kun; CAO Zhen-yan. ¹H and ¹³C NMR Chemical Shift Assignment for Tenatoprazole[J]. Chinese Journal of Magnetic Resonance, 2009, 26(3): 393-399.

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¹H and ¹³C NMR Chemical Shift Assignment for Tenatoprazole

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