Abstract: An NMR-based method for determining clarithromycin content in the capsules of the drug was developed. The linear range of the method was found to be 1.03~24.72 mg/mL. The regression equation derived was y=0.025 1X-0.026 (r=0.999 2). The average recovery rate was shown to be 98.7% (n=9), and the error was less than 0.2%. The results of this study showed that the NMR-based method for analyzing clarithromycin content has high sensitivity and good repeatability, and is easy to use.

Key words: NMR, internal standard, clarithromycin, quantification