Synthesis and NMR Studies of a Novel Chrysin-7-yl Phosphoramidate Derivative

Chinese Journal of Magnetic Resonance ›› 2009, Vol. 26 ›› Issue (2): 239-246.

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Synthesis and NMR Studies of a Novel Chrysin-7-yl Phosphoramidate Derivative

CHEN Xiao-lan¹; ZHANG Shou-ren¹; QU Ling-bo^1,2*; YUAN Jin-wei¹; ZHOU Ya-dong¹; LIU Nai-fang¹; ZHAO Yu-fen^1,3

(1.Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China; 2.School of Chemistry & Chemical Engineering, Henan University of Technology,
Zhengzhou 450052, China; 3.Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China)

Received:2008-11-10 Revised:2008-11-27 Online:2009-06-05 Published:2009-12-05
Contact: QU Ling-bo

Abstract

Abstract: In this study, the phosphorylated glycine methyl ester was coupled with chrysin to form a novel chrysin-7-yl phosphoramidate derivative by a facile phosphorylated reaction. Complete assignment of the ¹H and ¹³C NMR chemical shifts of the synthesized compound was obtained by 2D NMR techniques, including DEPT, ¹H-¹H COSY, ¹³C-¹H HSQC and ¹³C-¹H HMBC. ESI MS/MS spectra of the compound were also recorded and used to study its fragmentation behaviors.

Key words: NMR, assignment, 2D NMR, chrysin, phosphoramidate

CLC Number:

O657.61

O641

CHEN Xiao-lan¹; ZHANG Shou-ren¹; QU Ling-bo^1,2*; YUAN Jin-wei¹; ZHOU Ya-dong¹; LIU Nai-fang¹; ZHAO Yu-fen^1,3. Synthesis and NMR Studies of a Novel Chrysin-7-yl Phosphoramidate Derivative[J]. Chinese Journal of Magnetic Resonance, 2009, 26(2): 239-246.

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Synthesis and NMR Studies of a Novel Chrysin-7-yl Phosphoramidate Derivative

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