NMR Studies of Chiral Discrimination of Ibuprofen Enantiomers in β-Cyclodextrin Inclusion Complexes

Chinese Journal of Magnetic Resonance ›› 2009, Vol. 26 ›› Issue (2): 216-222.

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NMR Studies of Chiral Discrimination of Ibuprofen Enantiomers in β-Cyclodextrin Inclusion Complexes

WANG En-ju*; CHEN Guang-ying; PENG Ming-sheng

(Key Laboratory of Tropical Pharmaceutical Herb Chemistry of Hainan Province, Department of Chemistry, Hainan Normal University, Haikou 571158, China)

Received:2008-11-17 Revised:2008-12-16 Online:2009-06-05 Published:2009-12-05
Contact: WANG En-ju

Abstract

Abstract: The chiral recognition of racemic ibuprofen by β-cyclodextrin was studied by ¹H and ¹³C NMR spectroscopy. The ¹H and ¹³C spectra of ibuprofen complexing with β-cyclodextrin were shown to be different from those of free ibuprofen. Some peaks of the atoms adjacent to the chiral carbon atom showed splitting into two parts, corresponding to the two enantiomers of ibuprofen respectively. The result demonstrated that β-cyclodextrin can be used as a convenient and effectual chiral solvating agent.

Key words: NMR, β-cyclodextrin, ibuprofen, chrial discrimination, chiral solvating agent

CLC Number:

O657.2

WANG En-ju*; CHEN Guang-ying; PENG Ming-sheng. NMR Studies of Chiral Discrimination of Ibuprofen Enantiomers in β-Cyclodextrin Inclusion Complexes[J]. Chinese Journal of Magnetic Resonance, 2009, 26(2): 216-222.

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NMR Studies of Chiral Discrimination of Ibuprofen Enantiomers in β-Cyclodextrin Inclusion Complexes

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