An NMR Study on Cephalosporins

Chinese Journal of Magnetic Resonance ›› 2007, Vol. 24 ›› Issue (3): 347-352.

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An NMR Study on Cephalosporins

SHA Yi；ZHANG Peng；LI Ning；LI Wen；WANG Yu

NMR Laboratory, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2006-11-21 Revised:2007-01-17 Online:2007-09-05 Published:2009-12-05
Contact: Sha Yi

Abstract

Abstract: In this study, ¹H and ¹³C NMR spectra of three cephalosporins, cefotetan disodium, ceftriaxone and cefotaxime, were acquired and assigned. It was observed that the ¹³C NMR spectrum of cefotetan disodium showed evident signal splitting when DMSO-d₆ was used as the solvent and such signal splitting was absent with D₂O as the solvent. The results of variable temperature ¹³C NMR spectroscopy further demonstrated that the splitting of cefotetan disodium ¹³C signals was caused by that fact the compound has different conformations in DMSO-d₆.

Key words: NMR, chemical shift assignment, cefotetan disodium, ceftriaxone

SHA Yi；ZHANG Peng；LI Ning；LI Wen；WANG Yu. An NMR Study on Cephalosporins[J]. Chinese Journal of Magnetic Resonance, 2007, 24(3): 347-352.

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An NMR Study on Cephalosporins

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