Structure Elucidation of Valacyclovir Hydrochloride by NMR Spectroscopy and Mass Spectroscopy

Abstract

Abstract:

Valacyclovir hydrochloride, 2-[(2-amino-1，6-dihydro-6-oxo- 9H-purine-9-yl)methoxy] ethyl-L-valinate hydrochloride, was synthesized from purine through acetylation, hydrolysis, condensation and deprotection reactions. The structure of the target compound was elucidated by combined use of mass spectroscopy and 1D/2D NMR techniques including ¹H and ¹³C NMR, DEPT, ¹H-¹H COSY, HMQC and HMBC. The ¹H and ¹³C chemical shifts of the compound were completely assigned.

Key words: NMR, mass spectroscopy, valacyclovir, chemical shift assignment

CLC Number:

O641

Cite this article

LIU Li-Jun, ZHONG Bo-Hua, MIAO Zhen-Chun, CHEN Lan-Fu. Structure Elucidation of Valacyclovir Hydrochloride by NMR Spectroscopy and Mass Spectroscopy[J]. Chinese Journal of Magnetic Resonance, 2005, 22(3): 309-314.

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