AN NMR STUDY OF DEXAMETHASONE PALMITATE

Abstract

Abstract:

Dexamethasone palmitate incorporated into liposomes (liposteroid) was developed as a targeting antiinflammatory drug (limethason) used mainly for treatment of rheumatoid arthritis. In this study, 1D (¹H, ¹³C NMR and DEPT) and 2D (¹H-¹HCOSY，HMQC and HMBC) NMR spectra of dexamethasone palmitate in chloroform were obtained, assigned and analyzed. The structure of dexamethasone palmitate in chloroform was elucidated by referring to the ¹H and ¹⁹F NMR spectra of dexamethason in the aqueous solution, the standard ¹H and ¹³C NMR spectra of palmitate and the Lindeman-Adams experimental formula.

Key words: NMR, assignments, 2D NMR, dexamethasone palmitate

CLC Number:

O641

ZHANG Hai-Yan, WU Ming-Jian, DONG Jian-Jun, FU Jing-Guo, CHEN Chao, ZHAO Tian-Zeng. AN NMR STUDY OF DEXAMETHASONE PALMITATE[J]. Chinese Journal of Magnetic Resonance, 2004, 21(4): 405-411.

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