NMR Characteristics and Crystal Structure of Cytarabine HepDirect Prodrug MB07133

doi:10.11938/cjmr20150313

Abstract

Abstract:

The structure of the title compound (MB07133) was determined by one-dimensional (i.e., ¹H and ¹³C NMR) and two-dimensional (i.e., ¹H-¹H COSY, gHSQC and gHMBC) NMR techniques. The ¹H and ¹³C NMR chemical shifts were assigned. The crystal structure of the compound was determined using X-ray single crystal diffraction. The spectral feature and crystal structure of the compound, as well as the structure-function relationship with respective to its use as a prodrug, were discussed.

Key words: NMR, cytarabine HepDirect prodrug, MB07133, 2D NMR, crystal structure, single crystal diffraction

CLC Number:

O482.53

WANG Ming，WANG Min-chang*，ZHAO Xiao-jing，SU Peng-fei，PAN Qing，CHEN Zhi-qun，LI Xiao-yu. NMR Characteristics and Crystal Structure of Cytarabine HepDirect Prodrug MB07133[J]. Chinese Journal of Magnetic Resonance, 2015, 32(3): 518-527.

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