Structure and Function of Influenza Virus Fusion Peptide Studied by Nuclear Magnetic Resonance Spectroscopy

doi:10.11938/cjmr20140414

Abstract

Abstract:

The influenza fusion peptide plays a pivotal role in the fusion process of the viral membrane with the host-cell endosomal membrane. Recent success of solving the structure of influenza hemagglutinin fusion peptide has led to a new understanding of the fusion mechanism. Although a few hypotheses have been proposed, it is still of great interest to investigate the structure-function relationship of the fusion peptide. In this paper, the progresses in the field for the last decade is reviewed.

Key words: NMR, influenza fusion peptide, 3D structure, mechanism of fusion process

CLC Number:

O482.53

DU Tian-peng1,2，ZHANG Zi-wei1，ZENG Dan-yun1，LIU Mai-li1，JIANG Ling1*. Structure and Function of Influenza Virus Fusion Peptide Studied by Nuclear Magnetic Resonance Spectroscopy[J]. Chinese Journal of Magnetic Resonance, 2014, 31(4): 596-607.

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