An NMR Study of Phosphatidylcholine Small Unilamellar Vesicles

doi:10.11938/cjmr20140411

Abstract

Abstract:

Phosphatidylcholines (PC) is one of the most important phospholipids in the human and animal serum. It is the major constituent of lipoproteins that play important roles in the transport and metabolism of cholesterol. It was found that the many diseases, such as atherosclerosis, cancer, dementia and so on, were often associated with compositional and structural changes of phospholipids. Therefore, it is of interest to study the composition and structure of phospholipids. Here, small unilamellar vesicles (SUV) formed by PC were studied using 1D and 2D NMR experiments. It was found that there were two different [-N+(CH3)3] signals of PC, indicating that the SUV formed by PC may have a bilayer-spherical structure, not as previously thought to be a mono-layer structure.

Key words: NMR, bilayers, small unilamellar vesicles, phosphotidylcholine

CLC Number:

O482.53

LI Nan1,2，SUN Peng1,2，LIU Mai-li1，ZHANG Xu1*. An NMR Study of Phosphatidylcholine Small Unilamellar Vesicles[J]. Chinese Journal of Magnetic Resonance, 2014, 31(4): 572-578.

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