超极化129Xe自动收集-升华装置研究

doi:10.11938/cjmr20222998

摘要/Abstract

摘要：

因其较高的核自旋极化度所提供的探测灵敏度，超极化¹²⁹Xe气体已被成功应用于动物和人体磁共振成像（MRI）.但是，在超极化¹²⁹Xe的收集-升华过程中，多种因素会导致¹²⁹Xe核自旋弛豫，进而限制其应用范围.本文通过理论模型分析和实验测量，验证了温度、磁场、螺旋冷阱材质等对冷冻恢复过程中超极化¹²⁹Xe弛豫的影响；同时，测量了自动收集-升华装置的稳定性.研究结果表明，升华方式和冷阱材质对¹²⁹Xe极化度损耗的影响显著；自制收集-升华装置的自动化程度高、长时间稳定，¹²⁹Xe极化度的恢复率可达到85.6% ± 4.7%.本研究非常有助于提升超极化¹²⁹Xe在动物和人体MRI中的使用效率.

关键词: 磁共振成像, 超极化¹²⁹Xe气体, 自动收集-升华装置, 极化度恢复率

Abstract:

Due to the detection sensitivity provided by the high nuclear spin polarization, hyperpolarized ¹²⁹Xe has been employed in animal and human magnetic resonance imaging (MRI). However, during the accumulation-thawing process of hyperpolarized ¹²⁹Xe, multiple factors lead to the relaxation of spin polarization and would hinder the wider application of ¹²⁹Xe. In this research, the spin relaxation mechanism of hyperpolarized ¹²⁹Xe during the accumulation-thawing process is investigated by both theoretical model analysis and experimental measurements. Meanwhile, the stability of the homebuilt device for the accumulation-thawing is measured. Our results demonstrate that the thawing mode and the cold trap material significantly affect the polarization loss; the automatic device is very stable during long-term operation and shows a high degree of automation, resulting in a polarization recovery ratio of 85.6% ± 4.7%. This research greatly helps to improve the efficiency of hyperpolarized ¹²⁹Xe in animal and human MRI.

Key words: magnetic resonance imaging, hyperpolarized ¹²⁹Xe gas, automatic accumulation-thawing device, recovery ratios of polarization

中图分类号:

O482.53

陈小明, 赵修超, 孙献平, 谢军帅, 李海东, 韩叶清, 刘小玲, 陈琪, 周欣. 超极化¹²⁹Xe自动收集-升华装置研究[J]. 波谱学杂志, 2022, 39(3): 316-326.

Xiao-ming CHEN, Xiu-chao ZHAO, Xian-ping SUN, Jun-shuai XIE, Hai-dong LI, Ye-qing HAN, Xiao-ling LIU, Qi CHEN, Xin ZHOU. Study on the Automatic Accumulation-thawing Device of Hyperpolarized ¹²⁹Xe[J]. Chinese Journal of Magnetic Resonance, 2022, 39(3): 316-326.

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超极化¹²⁹Xe自动收集-升华装置研究

Study on the Automatic Accumulation-thawing Device of Hyperpolarized ¹²⁹Xe

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