基于动态有机钆纳米颗粒的T1-T2双模态MRI造影剂

doi:10.11938/cjmr20212902

摘要/Abstract

摘要：

本文设计、合成并测试了一种新型的基于有机钆纳米颗粒的磁共振成像（MRI）造影剂.以1, 2-氨基硫醇与氰基的缩合反应为基础，成功合成了粒径在8~23 nm范围内的有机钆纳米颗粒.该有机钆纳米颗粒作为磁共振造影剂时，随着时间的推移，其纵向弛豫率逐渐减弱，横向弛豫率先增强后逐渐减弱，这与钆纳米颗粒粒径增大有关.有机钆纳米颗粒同时存在随时间变化的纵向弛豫和横向弛豫，表明它有望成为一种先进的T₁-T₂双模态MRI造影剂.

关键词: 磁共振成像（MRI）, 造影剂, 双模态, 纳米颗粒

Abstract:

In this work, a new magnetic resonance imaging (MRI) contrast agent based on organic gadolinium (Gd) nanoparticles was designed, synthesized and tested. Based on a biocompatible condensation reaction between 1, 2-aminothiol and cyano group, organic Gd nanoparticles with well-controlled diameter in the range of 8~23 nm were successfully synthesized. When used as the MRI contrast agent, the organic Gd-nanoparticles exhibited slowly weakened longitudinal relaxivity with time. Meanwhile, its transverse relaxivity was observed to be enhanced firstly and then gradually weakened, which could be attributed to the diameter increase of the Gd-nanoparticles. The simultaneous existence of time-dependent longitudinal and transverse relaxivities of the organic Gd-nanoparticles suggests their potential to be advanced T₁-T₂ dual-modal contrast agent for MRI.

Key words: magnetic resonance imaging (MRI), contrast agent, dual modality, nanoparticle

中图分类号:

O482.53

张菊敏,陈世桢,周欣. 基于动态有机钆纳米颗粒的T₁-T₂双模态MRI造影剂[J]. 波谱学杂志, 2022, 39(1): 11-19.

Ju-min ZHANG,Shi-zhen CHEN,Xin ZHOU. Dual-modal MRI T₁-T₂ Contrast Agent Based on Dynamic Organic Gadolinium Nanoparticles[J]. Chinese Journal of Magnetic Resonance, 2022, 39(1): 11-19.

图/表 6

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基于动态有机钆纳米颗粒的T₁-T₂双模态MRI造影剂

Dual-modal MRI T₁-T₂ Contrast Agent Based on Dynamic Organic Gadolinium Nanoparticles

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